|A 5-year-old male presents for walking abnormalities. His parents observe that he is walking on his toes and his calves have become larger over the past 6 months. His serum creatine phosphokinase (CPK) level is 100 times the normal value. DNA testing confirms Duchenne muscular dystrophy (DMD). Further workup reveals hyperlordosis and scoliosis with a curve measuring 20°. Which of the following categories of medications is effective for preventing scoliosis curve progression?|
- Bisphosphonates Bisphosphonates inhibit osteoclasts and are the first-line of treatment for patients with osteoporosis.
Antibiotics are not used in treatment of patients with patients with neuromuscular scoliosis.
- Botulinum toxin
Botulinum toxin injections are used for a variety of spastic neuromuscular disorders, but not for treatment of neuromuscular scoliosis.
In patients with early DMD, corticosteroid therapy has been shown to stabilize muscle strength and should be initiated to maintain ambulatory capacity and prevent curve progression.