Challenge of the Week / Knee / 09.18.2020

A 65-year-old male patient undergoes primary total knee arthroplasty. As part of the perioperative blood management strategy, tranexamic acid (TXA) will be administered. Which of the following best describes the different formulations of TXA??
    • Oral administration of TXA is the most expensive.
    • Oral administration of TXA is the least expensive route of administration.

 

    • Intravenous administration of TXA provides the greatest reduction in blood loss.
    • A recent network meta-analysis by Fillingham, et al. showed a significant reduction in blood loss and risk of transfusion compared with placebo, with no clear difference observed between the available formulations of TXA.

 

    • Topical administration is associated with the lowest rate of blood transfusion.
    • A recent network meta-analysis by Fillingham, et al. showed a significant reduction in blood loss and risk of transfusion compared with placebo, with no clear difference observed between the available formulations of TXA.

 

    • There is no difference in efficacy between formulations of TXA.
    • A recent network meta-analysis by Fillingham, et al. showed a significant reduction in blood loss and risk of transfusion compared with placebo, with no clear difference observed between the available formulations of TXA.

     

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