Challenge of the Week / Basic Science / 04.30.21

Aggrecan is the major proteoglycan in cartilage and forms stable complexes in the extracellular matrix by interacting with the nonsulfated glycosaminoglycan, hyaluronic acid. Hyaluronic acid can interact with chondrocytes by binding to which of the following chondrocyte membrane receptors?

    • CD44
    • CD44 is a major cell surface receptor for hyaluronic acid and is homologous to cartilage-link proteins.


    • Integrin alpha 5 beta 1
    • Integrin receptor (alpha 5 beta 1) binds to fibronectin.


    • DDR2
    • DDR2 (discoidin domain receptor 2) is a tyrosine kinase receptor that interacts with fibrillar collagens, including type-II collagen.


    • IGF-1 receptor
    • IGF-1 receptor ligands are insulin-like growth factors 1 and 2 (IGF-1, IGF-2).


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