Challenge of the Week / Basic Science / 07.16.21

The gastrointestinal tract microbiome has been implicated in the pathogenesis of osteoporosis through which of the following mechanisms?

    • Impacts serum vitamin D levels
    • The microbiome has been hypothesized to play a role in vitamin D absorption; however, studies have been unable to demonstrate a clear association.

 

    • Inhibits osteoclastic activity
    • Although it may play a role in osteoclastic activity, studies have not demonstrated a role for the microbiome in direct regulation of osteoclastic activity.

 

    • Enhances osteoblast activity
    • Although it may play a role in regulating osteoblast activity, studies have not demonstrated a role for the microbiome in direct regulation of osteoblast activity.

 

    • Influences absorption of calcium from the digestive tract
    • Variation in the microbiome influences the uptake of calcium from the gastrointestinal tract, which may impact the development of osteoporosis.

     

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