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A patient undergoing orthopaedic surgery experiences acute decompensation intra-operatively that is mitigated with hyperoxygenation and serial injections of dantrolene. Susceptibility to which of the following conditions may be identified in this patient’s family? |
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- Malignant hyperthermia Malignant hyperthermia (MH) is a potentially fatal condition that occurs in susceptible individuals with an autosomal dominantly inherited mutation in skeletal muscle ryanodine receptors.
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- Fat embolism syndrome Fat embolism syndrome (FES) is treated with supportive care that includes respiratory support, but dantrolene has no role in FES.
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- Lidocaine toxicity Toxicities from local anesthetics, especially cardiac events, are treated with infusion of lipid emulsion.
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- Ischemia/reperfusion injury Dantrolene has been sparsely studied in ischemia/reperfusion injuries to tissues other than skeletal muscle, but family history would not be contributory to ischemia/reperfusion injury.
