The JBJS Quiz of the Month is a collection of 10 relevant questions from each orthopaedic subspecialty. The questions are drawn from JBJS Clinical Classroom, which houses over 4,500 questions and 3,100 learning resources. Take the Quiz to see how you score against your peers!

NOTE: This quiz does not earn users CME credits. The questions must be answered within Clinical Classroom to earn CME credits.

If there is a gene defect in the Wnt gene causing decreased binding of Wnt to its receptor on the osteoblast cell surface, which of the following is the outcome?

    • Hard but brittle bone
    • Reports have linked mutations in the WNT1 gene (not receptors) to osteogenesis imperfecta, a disease characterized by the presence of brittle bone that is easily fractured.

 

    • Increased ligamentous laxity
    • The Wnt pathway is not currently associated with significant clinical pathological manifestations in ligaments.

 

    • Decreased peak bone mass and earlier-onset osteoporosis
    • Loss-of-function mutations in LRP5 receptors found in the Wnt receptor complexes are associated with changes in bone mineral density and fractures and cause osteoporosis-pseudoglioma syndrome.

 

    • Increased peak bone mass and decreased risk of osteoporosis
    • Loss–of-function mutations in LRP5 receptors found in the Wnt receptor complexes are associated with changes in bone mineral density and fractures and cause osteoporosis-pseudoglioma syndrome.

     

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